Bouhlel Aicha, Joumaa Wissam H, Léoty Claude
Laboratoire de Physiologie Générale, UMR CNRS 6018, Faculté des Sciences et des Techniques, Université de Nantes, 2 rue de la Houssinière, BP 92208, 44322, Nantes Cedex 3, France.
Pflugers Arch. 2003 Sep;446(6):728-34. doi: 10.1007/s00424-003-1114-z. Epub 2003 Jun 17.
The effects of anabolic-androgenic steroid administration on the function of the sarcoplasmic reticulum (SR) pump were investigated in chemically skinned fibres from the extensor digitorum longus (EDL) and soleus muscles of sedentary rats. Twenty male rats were divided into two groups, one group received an intramuscular injection of nandrolone decanoate (15 mg x kg(-1)) weekly for 8 weeks, the second received similar weekly doses of vehicle (sterile peanut oil). Compared with control muscles, nandrolone decanoate treatment reduced SR Ca(2+) loading in EDL and soleus fibres by 49% and 29%, respectively. In control and treated muscles, the rate of Ca(2+) leakage depended on the quantity of Ca(2+) loaded. Furthermore, for similar SR Ca(2+) contents, the Ca(2+) leakage rate was not significantly modified by nandrolone decanoate treatment. Nandrolone decanoate treatment thus affects Ca (2+) uptake by the SR in a fibre-type dependent manner.
研究了合成代谢雄激素类固醇给药对久坐大鼠趾长伸肌（EDL）和比目鱼肌化学去表皮纤维中肌浆网（SR）泵功能的影响。将20只雄性大鼠分为两组，一组每周肌肉注射癸酸诺龙（15 mg x kg(-1)），共8周，另一组每周注射相似剂量的溶媒（无菌花生油）。与对照肌肉相比，癸酸诺龙处理使EDL和比目鱼肌纤维中的SR Ca(2+)负载分别降低了49%和29%。在对照和处理的肌肉中，Ca(2+)泄漏率取决于Ca(2+)负载量。此外，对于相似的SR Ca(2+)含量，癸酸诺龙处理并未显著改变Ca(2+)泄漏率。因此，癸酸诺龙处理以纤维类型依赖的方式影响SR对Ca(2+)的摄取。
