Crooks S M, Wu Xiaodong, Takita C, Watzich M, Xing Lei
Department of Radiation Oncology, Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA.
Phys Med Biol. 2003 May 21;48(10):1333-44. doi: 10.1088/0031-9155/48/10/307.
We show that it is possible to translate an intensity modulated radiation therapy (IMRT) treatment plan and deliver it as a single arc. This technique is referred to in this paper as aperture modulation arc therapy (AMAT). During this arc, the MLC leaves do not conform to the projection of the target PTV and the machine output of the accelerator has a constant value. Dose was calculated using the CORVUS 4.0 IMRT system, which uses a pencil beam dose algorithm, and treatments were delivered using a Varian 2100C/D Clinac. Results are presented for a head and neck and a prostate case, showing the equivalence of the IMRT and the translated AMAT delivery. For a prostate AMAT delivery, coronal plane film dose for the IMRT and AMAT deliveries agreed within 7.19 +/- 6.62%. For a meningioma the coronal plane dose distributions were similar to a value of 4.6 +/- 6.62%. Dose to the isocentre was measured as being within 2% of the planned value in both cases.
我们证明了可以将调强放射治疗（IMRT）治疗计划进行转换并作为单弧进行照射。本文将该技术称为孔径调制弧光治疗（AMAT）。在这个弧光照射过程中，多叶准直器叶片并不与靶区计划靶体积（PTV）的投影相符，且加速器的机器输出具有恒定值。剂量使用采用笔形束剂量算法的CORVUS 4.0 IMRT系统进行计算，并使用瓦里安2100C/D直线加速器进行照射。给出了头颈部和前列腺病例的结果，显示了IMRT和转换后的AMAT照射的等效性。对于前列腺AMAT照射，IMRT和AMAT照射的冠状面胶片剂量在7.19±6.62%的范围内一致。对于脑膜瘤，冠状面剂量分布相似，差值为4.6±6.62%。在这两种情况下，测量到的等中心剂量在计划值的2%以内。
