用铂（IV）抗癌剂处理的癌细胞中铂氧化态分布的X射线吸收近边结构测定
XANES determination of the platinum oxidation state distribution in cancer cells treated with platinum(IV) anticancer agents.
作者信息
Hall Matthew D, Foran Garry J, Zhang Mei, Beale Philip J, Hambley Trevor W
机构信息
Centre for Heavy Metals Research, School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia.
出版信息
J Am Chem Soc. 2003 Jun 25;125(25):7524-5. doi: 10.1021/ja0354770.
Here we describe the use of X-ray absorption near edge spectroscopy (XANES) to provide information about the relative proportions of platinum(II) and platinum(IV) complexes by analyzing the XANES edge height. The intracellular reduction of platinum(IV) complexes in cancer cells has been observed directly, and the proportion of reduction after 2 h was found to correlate with the reduction potentials of the complexes.
在此，我们描述了利用X射线吸收近边光谱法（XANES），通过分析XANES边高来提供有关铂（II）和铂（IV）配合物相对比例的信息。已直接观察到癌细胞中铂（IV）配合物的细胞内还原情况，并且发现2小时后的还原比例与配合物的还原电位相关。
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