西非和非洲加勒比裔患者中的白塞病。
Behçet's disease in patients of west African and Afro-Caribbean origin.
作者信息
Poon W, Verity D H, Larkin G L, Graham E M, Stanford M R
机构信息
Department of Ophthalmology, St Thomas's Hospital, London, UK.
出版信息
Br J Ophthalmol. 2003 Jul;87(7):876-8. doi: 10.1136/bjo.87.7.876.
AIM
To report the presence of Behçet's disease with ocular involvement in patients of west African or Afro-Caribbean origin.
METHODS
Case series of eight patients reporting to a tertiary uveitis service.
RESULTS
Eight patients with typical features of the disease are presented. Six of the eight patients were tested and found to be HLA-B51 negative.
CONCLUSION
Behçet's disease has only been reported in sporadic case reports in the indigenous west African and Afro-Caribbean populations, in whom the incidence of HLA B51 is also very low. A series of patients from the London region presented with the typical symptoms and signs of disease, most of whom were also HLA B51 negative. The presence of disease in this population, when absent in the indigenous population, suggests either that ascertainment of disease is poor in the indigenous population or that acquired factors may be important in the aetiology of the disease.
目的
报告西非或非洲加勒比裔患者中伴有眼部受累的白塞病情况。
方法
向一家三级葡萄膜炎诊疗机构就诊的8例患者的病例系列。
结果
呈现8例具有该病典型特征的患者。8例患者中的6例接受检测，发现HLA - B51阴性。
结论
白塞病仅在散发病例报告中见于西非和非洲加勒比裔本土人群，其中HLA B51的发生率也很低。伦敦地区的一系列患者表现出该病的典型症状和体征，其中大多数HLA B51也为阴性。该人群中存在该病而本土人群中不存在，这表明要么本土人群对该病的确诊率低，要么后天因素在该病病因中可能很重要。
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