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[苛性物质中毒]

[Posioning by caustic substances].

作者信息

Mencías E

机构信息

Servicio de Información Toxicológica, Instituto Nacional de Toxicología, 28002 Madrid, Spain.

出版信息

An Sist Sanit Navar. 2003;26 Suppl 1:191-207.

Abstract

There are discordant guides and protocols when it comes to treating a patient who has ingested a caustic substance. Different ideas or tendencies speak in favour of dilution, neutralization, provoking vomiting, carrying out stomach washes, etc., depending on the milieu where the problem arises: at home, at the health centre, emergency service or hospital. The same occurs with the type of diluent or neutralizing agent to be used, how and when to start the treatment pattern with corticoids and/or antibiotics and antisecretory, if indeed this is necessary. We have carried out an exhaustive bibliographical study, an experimental work and a study of the different diagnosis and treatment guides and protocols used in different Spanish hospitals. At the experimental level it was found that there are histopathological markers that advise against the use of diluent substances following the ingestion of caustic alkali. Except in the cases of ingestion of solid caustic substances -crystalline or granulated- categorical contraindications are given against dilution. Corticoids are not efficient when a caustic acid is ingested; their use is more than questionable following the ingestion of caustic alkali. Diagnosis and quality of treatment are based on endoscopy. There is no single criterion that defines which moment (the time following ingestion) is the most convenient for carrying this out, although the period between the first 6-12 hours is the most suitable. We present an independent protocol of diagnosis and treatment -in the form of algorithms- that must be followed after the ingestion of caustic acids or caustic alkali.

摘要

在治疗摄入腐蚀性物质的患者时,存在不一致的指南和方案。根据问题出现的环境(在家中、健康中心、急救服务机构或医院)不同,对于稀释、中和、催吐、洗胃等措施,有不同的观点或倾向。对于所使用的稀释剂或中和剂类型、如何以及何时开始使用皮质类固醇和/或抗生素以及抗分泌药物(如果确实有必要)进行治疗,情况也是如此。我们进行了详尽的文献研究、实验工作,并研究了西班牙不同医院使用的不同诊断和治疗指南及方案。在实验层面发现,存在一些组织病理学标志物,提示在摄入苛性碱后不宜使用稀释物质。除了摄入固体腐蚀性物质(结晶状或颗粒状)的情况外,明确禁止进行稀释。摄入苛性酸时,皮质类固醇无效;摄入苛性碱后使用皮质类固醇更是存在很大疑问。诊断和治疗质量基于内窥镜检查。虽然最初6至12小时是最合适的时间段,但对于何时(摄入后时间)进行内窥镜检查最为合适,并没有单一的标准来界定。我们以算法的形式呈现了一个独立的诊断和治疗方案,在摄入苛性酸或苛性碱后必须遵循该方案。

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