Buø L, Karlsrud T S, Johansen H T, Aasen A O
Institute for Surgical Research, University of Oslo, Norway.
Agents Actions Suppl. 1992;38 ( Pt 2):237-48.
Our observations indicates that the plasma contact system is activated in ascites from patients with gastrointestinal cancer: Factor XII is activated, plasma kallikrein is present in complex with the protease inhibitor alpha 2-macroglobulin, and the plasma kallikrein substrate high molecular weight kininogen, is highly degraded. Contact activation seems to take place in spite of a high level of inhibition. Activation of the contact system generates mediators, which may play a role in the accumulation of ascites.
我们的观察结果表明，胃肠道癌患者腹水中的血浆接触系统被激活：凝血因子 XII 被激活，血浆激肽释放酶与蛋白酶抑制剂α2-巨球蛋白形成复合物，并且血浆激肽释放酶底物高分子量激肽原被高度降解。尽管存在高水平的抑制作用，但接触激活似乎仍会发生。接触系统的激活产生介质，这些介质可能在腹水的积聚中起作用。
