Buø L, Karlsrud T S, Johansen H T, Aasen A O
Institute for Surgical Research, Rikshospitalet, Oslo, Norway.
Scand J Clin Lab Invest. 1993 Apr;53(2):117-24. doi: 10.3109/00365519309088398.
The plasma contact system was studied in ascites and plasma from patients with gastrointestinal cancer and patients with liver failure. Our study demonstrates the presence of factor XII, factor XI, and prekallikrein and their main inhibitors in ascites and plasma from both patient groups. Both factor XII-like and plasma kallikrein-like activities were detected in the malignant ascites. The kallikrein-like activity in malignant ascites was found in complex with alpha 2-macroglobulin. In plasma samples from the patients functional values of factor XII and prekallikrein were decreased compared to controls. In benign ascites the proenzyme levels were significantly lower than in malignant ascites. Functional inhibition values in ascites and plasma from patients were unexpectedly high. Our findings indicate that the plasma contact system is activated in the ascites from cancer patients. Activation of the contact system generates vasoactive mediators, which may play a role in the accumulation of malignant ascites.
对胃肠道癌患者和肝衰竭患者的腹水及血浆中的血浆接触系统进行了研究。我们的研究表明，两组患者的腹水和血浆中均存在因子 XII、因子 XI 和前激肽释放酶及其主要抑制剂。在恶性腹水中检测到了类似因子 XII 和类似血浆激肽释放酶的活性。在恶性腹水中发现类似激肽释放酶的活性与α2-巨球蛋白结合。与对照组相比，患者血浆样本中因子 XII 和前激肽释放酶的功能值降低。在良性腹水中，酶原水平显著低于恶性腹水。患者腹水和血浆中的功能抑制值意外地高。我们的研究结果表明，癌症患者腹水中的血浆接触系统被激活。接触系统的激活产生血管活性介质，这可能在恶性腹水的积聚中起作用。
