Vermeulen Katrien, Berneman Zwi N, Van Bockstaele Dirk R
Faculty of Medicine, Laboratory of Experimental Hematology, University of Antwerp, Antwerp University Hospital, Edegem, Belgium.
Cell Prolif. 2003 Jun;36(3):165-75. doi: 10.1046/j.1365-2184.2003.00267.x.
Apoptosis and proliferation are intimately coupled. Some cell cycle regulators can influence both cell division and programmed cell death. The linkage of cell cycle and apoptosis has been recognized for c-Myc, p53, pRb, Ras, PKA, PKC, Bcl-2, NF-kappa B, CDK, cyclins and CKI. This review summarizes the different functions of the proteins presently known to control both apoptosis and cell cycle progression. These proteins can influence apoptosis or proliferation but different variables, including cell type, cellular environment and genetic background, make it difficult to predict the outcome of cell proliferation, cell cycle arrest or cell death. These important decisions of cell proliferation or cell death are likely to be controlled by more than one signal and are necessary to ensure a proper cellular response.
细胞凋亡与增殖紧密相关。一些细胞周期调节因子可同时影响细胞分裂和程序性细胞死亡。细胞周期与细胞凋亡之间的联系已在c-Myc、p53、pRb、Ras、蛋白激酶A（PKA）、蛋白激酶C（PKC）、Bcl-2、核因子κB（NF-κB）、细胞周期蛋白依赖性激酶（CDK）、细胞周期蛋白和细胞周期蛋白依赖性激酶抑制剂（CKI）中得到确认。本综述总结了目前已知的既能控制细胞凋亡又能调控细胞周期进程的蛋白质的不同功能。这些蛋白质可影响细胞凋亡或增殖，但包括细胞类型、细胞环境和遗传背景在内的不同变量，使得难以预测细胞增殖、细胞周期停滞或细胞死亡的结果。细胞增殖或细胞死亡的这些重要决定可能受不止一种信号控制，并且对于确保适当的细胞反应是必要的。
