Westrin Asa, Niméus Anders
Department of Clinical Neuroscience, Division of Psychiatry, Lund University, 221 85 Lund, Sweden.
Eur Psychiatry. 2003 Jun;18(4):166-71. doi: 10.1016/s0924-9338(03)00044-0.
This study tested suicidality in relation to cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA) and the dexamethasone suppression test. Patients with nonsuppression of cortisol had the highest scores of the Suicide Assessment Scale (SUAS) and the Montgomery Asberg Depression Rating Scale (MADRS), respectively (P < 0.05; P < 0.01). The results persisted when analysed for covariance with CSF-5-HIAA. We have previously noted an elevated suicide risk in suicide attempters with high SUAS-scores, why a large part of nonsuppressors may be at high risk for future suicide.
本研究检测了与脑脊液（CSF）5-羟吲哚乙酸（5-HIAA）及地塞米松抑制试验相关的自杀倾向。皮质醇未被抑制的患者在自杀评估量表（SUAS）和蒙哥马利-艾斯伯格抑郁评定量表（MADRS）上分别得分最高（P<0.05；P<0.01）。在对CSF-5-HIAA进行协方差分析时，该结果依然存在。我们之前注意到，SUAS得分高的自杀未遂者自杀风险升高，因此很大一部分未被抑制者未来可能有很高的自杀风险。
