Thompson Peter M, Kelley Mary, Yao Jeffrey, Tsai Guochuan, van Kammen Daniel P
Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.
Biol Psychiatry. 2003 Jun 15;53(12):1132-7. doi: 10.1016/s0006-3223(02)01599-8.
Research suggests an association between abnormal exocytosis and schizophrenia. We previously demonstrated increased synaptosomal associated protein, 25 kDa (SNAP-25), a member of the exocytotic mechanism, in the cerebrospinal fluid (CSF) of schizophrenia subjects. In this study, we explored SNAP-25 level and clinical variables in a new group of subjects.
Twenty-five haloperidol-treated subjects with chronic schizophrenia and twenty-five healthy control subjects participated in the study. Subjects received haloperidol treatment for at least 3 months and then had a lumbar puncture (n = 19). Medication was replaced by placebo, and the lumbar puncture was repeated (n = 25) after 6 weeks or sooner if limited psychotic symptoms occurred. We measured the level of SNAP-25 in the CSF and symptoms with the Brief Psychiatric Rating Scale (BPRS).
In both haloperidol (p =.001) and placebo (p =.001) treatment conditions, SNAP-25 was elevated. There was no significant difference in SNAP-25 level between conditions. We identified significant positive correlations among SNAP-25 and the BPRS total score and psychosis and thinking disturbance subscales in subjects on haloperidol.
These observations confirm our previous report of elevated CSF SNAP-25 and suggest that synaptic pathology may be linked with the pathophysiology of schizophrenia.
研究表明异常胞吐作用与精神分裂症之间存在关联。我们先前证明，精神分裂症患者脑脊液（CSF）中胞吐机制成员之一的突触体相关蛋白25 kDa（SNAP - 25）有所增加。在本研究中，我们在一组新的受试者中探究了SNAP - 25水平和临床变量。
25名接受氟哌啶醇治疗的慢性精神分裂症患者和25名健康对照受试者参与了该研究。受试者接受氟哌啶醇治疗至少3个月，然后进行腰椎穿刺（n = 19）。药物被安慰剂替代，若出现有限的精神病性症状，则在6周或更早时间重复进行腰椎穿刺（n = 25）。我们用简明精神病评定量表（BPRS）测量脑脊液中SNAP - 25的水平和症状。
在氟哌啶醇（p =.001）和安慰剂（p =.001）治疗条件下，SNAP - 25均升高。两种条件下SNAP - 25水平无显著差异。我们发现接受氟哌啶醇治疗的受试者中，SNAP - 25与BPRS总分、精神病性及思维障碍分量表之间存在显著正相关。
这些观察结果证实了我们之前关于脑脊液中SNAP - 25升高的报告，并表明突触病理学可能与精神分裂症的病理生理学有关。
