Berggren Ulf, Berglund Kristina, Eriksson Matts, Fahlke Claudia, Zachrisson Olof, Balldin Jan
The Sahlgrenska Academy at Göteborg University, Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Mölndal, SE - 431 80 Mölndal, Sweden.
Alcohol Alcohol. 2003 Jul-Aug;38(4):321-6. doi: 10.1093/alcalc/agg086.
In the present study, alpha(2)-adrenoceptor function was investigated over 6 months of sobriety in eight male alcohol-dependent subjects.
Subjects were investigated with repeated clonidine (CLON, 2 micro g/kg body weight intravenously) challenge tests at days 1 and 7, and months 2 and 6 after the end of a period of heavy alcohol intake. CLON-induced sedation was rated at challenge tests. Mental well-being was self-reported before all challenge tests. Three challenge tests were performed at 1-week intervals in six male healthy controls.
Sedation was significantly lower after CLON at all time-points for the challenge tests in alcohol-dependent subjects compared with mean values for three challenge tests in controls. Three dimensions of mental well-being were negatively correlated with scores of CLON-induced sedation at month 6.
alpha(2)-Adrenoceptor function is subnormal, as assessed by CLON-induced sedation, for at least 6 months after termination of alcohol intake. Whether this subnormal receptor function is pre-existing and possibly genetically determined or is a consequence of long-term alcohol intake must be further investigated, as should this receptor status in alcohol-dependent subjects with longer time-periods of sobriety.
在本研究中，对8名男性酒精依赖者戒酒6个月期间的α₂-肾上腺素能受体功能进行了研究。
在大量饮酒期结束后的第1天和第7天，以及第2个月和第6个月，对受试者进行重复的可乐定（CLON，静脉注射2μg/kg体重）激发试验。在激发试验中对可乐定诱导的镇静作用进行评分。在所有激发试验前，让受试者自行报告心理健康状况。对6名男性健康对照者每隔1周进行3次激发试验。
与对照组3次激发试验的平均值相比，酒精依赖者在所有时间点的可乐定激发试验后的镇静作用均显著降低。在第6个月时，心理健康的三个维度与可乐定诱导的镇静评分呈负相关。
通过可乐定诱导的镇静作用评估，戒酒至少6个月后α₂-肾上腺素能受体功能仍低于正常水平。这种低于正常的受体功能是预先存在的且可能由基因决定，还是长期饮酒的结果，必须进一步研究，同时也应研究戒酒时间更长的酒精依赖者的这种受体状态。
