Fahlke C, Berggren U, Balldin J
Department of Psychology, Göteborg University, P.O. Box 500, SE-405 30, Goteborg, Sweden.
Alcohol. 2000 Jul;21(3):231-7. doi: 10.1016/s0741-8329(00)00088-4.
The possible relationships between alpha-2-adrenoceptor function, as assessed by blood pressure, heart rate, and sedative responses to clonidine (CLON; 1.5 microg/kg, i.v.), and psychopathology and mental well-being were investigated in 19 patients with alcohol-dependence in the early withdrawal period (days 1 and 7). An age-matched control group was used (n=17). CLON-induced maximum reduction of systolic blood pressure was less day 1 in the alcohol-dependent patients compared to controls. CLON was found to induce less sedation at day 7 compared to day 1 and to controls. No relationships were seen between the parameters for alpha-2-adrenoceptor function and psychopathology and mental well-being. These findings suggest that CLON-induced changes in blood pressures and heart rate reflect the cardiovascular situation in alcohol withdrawal and not aspects of behavior.
在19例处于早期戒断期（第1天和第7天）的酒精依赖患者中，研究了通过血压、心率以及对可乐定（CLON；1.5微克/千克，静脉注射）的镇静反应评估的α-2肾上腺素能受体功能与精神病理学及心理健康之间的可能关系。使用了年龄匹配的对照组（n = 17）。与对照组相比，酒精依赖患者在第1天CLON诱导的收缩压最大降幅较小。发现与第1天及对照组相比，CLON在第7天诱导的镇静作用较小。未观察到α-2肾上腺素能受体功能参数与精神病理学及心理健康之间的关系。这些发现表明，CLON引起的血压和心率变化反映了酒精戒断时的心血管状况，而非行为方面。
