Sloan Tracy B, Roache John D, Johnson Bankole A
University of Texas Health Science Center, START Center, 7703 Floyd Curl Drive, Mail Stop 7792, San Antonio, TX 78229, USA.
Alcohol Alcohol. 2003 Jul-Aug;38(4):360-3. doi: 10.1093/alcalc/agg090.
We investigated whether reduced anxiety predicted improved drinking outcomes over and above age of onset and ondansetron treatment among alcoholics enrolled in a clinical trial.
Study design was a 2 (early onset alcoholics versus late onset alcoholics) x 4 (placebo and ondansetron 1, 4 and 16 micro g/kg twice daily) factorial randomized clinical trial during which all participants received weekly group cognitive behavioural therapy. Using weighted least squares regression, we examined the effects of ondansetron dose, age of onset, pre-treatment drinking and anxiety level (measured by Profile of Mood States) on end-state drinking behaviour. Our previous studies have demonstrated that ondansetron dose, age of onset and pre-treatment drinking influence end-state drinking behaviour.
and conclusions: The present study added to our previous knowledge, indicating that when change in anxiety level was included as a predictor of end-state drinking, it also accounted for a significant proportion of the variance. Those who experienced decreases in anxiety during the treatment reported fewer drinks per day at their last visit compared with those who reported increases in anxiety.
我们调查了在一项临床试验中，除了发病年龄和昂丹司琼治疗外，焦虑减轻是否能预测酗酒者饮酒结果的改善。
研究设计为一项2（早发性酗酒者与晚发性酗酒者）×4（安慰剂以及每日两次1、4和16微克/千克的昂丹司琼）析因随机临床试验，在此期间所有参与者每周接受团体认知行为疗法。使用加权最小二乘回归，我们研究了昂丹司琼剂量、发病年龄、治疗前饮酒情况和焦虑水平（通过情绪状态剖面图测量）对最终饮酒行为的影响。我们之前的研究表明，昂丹司琼剂量、发病年龄和治疗前饮酒情况会影响最终饮酒行为。
本研究丰富了我们之前的认识，表明当将焦虑水平的变化作为最终饮酒行为的预测指标时，它也占了很大一部分方差。与报告焦虑增加的人相比，在治疗期间焦虑减轻的人在最后一次就诊时每天饮酒量更少。
