Chen T-Y, Chen J-S, Huang W-T, Su W-C, Tsao C-J
Division of Hematology/Oncology, Department of Internal Medicine, National Cheng-Kung University Hospital, Tainan, Taiwan.
Bone Marrow Transplant. 2003 Jul;32(1):111-4. doi: 10.1038/sj.bmt.1704098.
Mastocytosis is a rare disease characterized by an abnormal increase of mast cells in tissues. We report a case of acute myeloid leukemia (AML) with t(8;21) and mast cell leukemia (MCL) in which the mastocytosis persisted after standard chemotherapy and allogeneic stem cell transplantation, although the myeloid leukemia achieved molecular complete remission soon after induction chemotherapy. Donor-type mast cells were noted on d31 after transplant. No c-kit mutation was found before or after the transplant. This represents the first reported case in which rapid engraftment of mast cells of donor origin was documented. Thus, the possibility that the mast cell originates from a common myeloid precursor cell may be questioned and a reactive process should be considered in some cases of systemic mastocytosis.
肥大细胞增多症是一种罕见疾病，其特征为组织中肥大细胞异常增多。我们报告一例伴有t(8;21)的急性髓系白血病（AML）和肥大细胞白血病（MCL）病例，尽管诱导化疗后髓系白血病很快达到分子完全缓解，但标准化疗和异基因干细胞移植后肥大细胞增多症仍持续存在。移植后第31天发现供体来源的肥大细胞。移植前后均未发现c-kit突变。这是首次报道记录到供体来源肥大细胞快速植入的病例。因此，肥大细胞起源于常见髓系前体细胞的可能性可能受到质疑，在某些系统性肥大细胞增多症病例中应考虑反应性过程。
