Brunstein C G, Hirsch B A, Hammerschmidt D, McGlennen R C, Nguyen P L, Verfaillie C M
Division of Hematology, Oncology and Transplantation, Department of Medicine University of Minnesota, Minneapolis, MN 55455, USA.
Bone Marrow Transplant. 2002 Jun;29(12):999-1003. doi: 10.1038/sj.bmt.1703577.
The development of leukemia in donor cells after allogeneic hematopoietic stem cell transplant is an extremely rare event. We report here the case of a patient who developed myelodysplastic syndrome/acute myeloid leukemia, in cells of donor origin 3.5 years after related donor HSCT for refractory chronic lymphocytic leukemia and therapy-induced myelodysplastic syndrome. The origin of the leukemia was determined by analysis of minisatillite polymorphism tested on CD34(+) cells.
异基因造血干细胞移植后供体细胞发生白血病是极为罕见的事件。我们在此报告一例患者，该患者在因难治性慢性淋巴细胞白血病和治疗相关性骨髓增生异常综合征接受相关供体造血干细胞移植3.5年后，供体来源的细胞发生了骨髓增生异常综合征/急性髓系白血病。通过对CD34(+)细胞进行小卫星多态性分析确定了白血病的起源。
