Sánchez Otto, Guerra Dania
Centro de Microscopía Electrónica, Núcleo Bolívar, Universidad de Oriente, Apartado 83, Ciudad Bolívar, Venezuela 8001-A.
Invest Clin. 2003 Jun;44(2):147-53.
We report a patient affected with Moebius Syndrome (OMIM 157900) due to the use of misoprostol during the first trimester of the pregnancy, when abortion was intended twice using this drug, vias vaginal (600 mg) and oral (900 mg), with failure to induce abortion on both occasions. Since the use of misoprostol for abortion, without any medical indication or supervision, appears to be rather frequent in our population and since there are reports of severe malformations in children born after failed intents of abortion with this medication, it is necessary to alert the medical community and the population in general about the teratogenic risks of this drug.
我们报告了一名患有莫比乌斯综合征（OMIM 157900）的患者，病因是在妊娠早期使用了米索前列醇，当时两次试图使用该药物进行流产，一次经阴道给药（600毫克），一次口服给药（900毫克），但两次均未能成功诱导流产。由于在我们的人群中，无任何医学指征或监管情况下使用米索前列醇进行流产似乎相当常见，且有报道称使用该药物流产未遂后出生的儿童出现严重畸形，因此有必要就该药物的致畸风险向医学界和普通民众发出警示。
