[Modeling viability of mammalian cells exposed to ionizing radiation with different linear energy transfer].

A mathematical model of the survival of mammalian cells exposed to ionizing radiation is proposed, which takes into account nonuniform radiosensitivity of different regions of DNA. The model is based on the assumption that the double-strand breaks of the anchor DNA, induced either directly by irradiation or by enzymes, play a key role in the lethal radiation effect. The model survival curves are in good agreement with experimental curves measured in different laboratories.