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[模拟暴露于不同线性能量传递的电离辐射下哺乳动物细胞的活力]

[Modeling viability of mammalian cells exposed to ionizing radiation with different linear energy transfer].

作者信息

Bodnarchuk I A

机构信息

Joint Institute for Nuclear Research, ul. Joliot-Curie 6, Dubna, Moscow Region, 141980 Russia.

出版信息

Biofizika. 2003 May-Jun;48(3):474-9.

PMID:12815858
Abstract

A mathematical model of the survival of mammalian cells exposed to ionizing radiation is proposed, which takes into account nonuniform radiosensitivity of different regions of DNA. The model is based on the assumption that the double-strand breaks of the anchor DNA, induced either directly by irradiation or by enzymes, play a key role in the lethal radiation effect. The model survival curves are in good agreement with experimental curves measured in different laboratories.

摘要

提出了一个哺乳动物细胞暴露于电离辐射下的存活数学模型，该模型考虑了DNA不同区域的非均匀放射敏感性。该模型基于这样的假设：由辐射直接诱导或由酶诱导的锚定DNA双链断裂在辐射致死效应中起关键作用。模型存活曲线与不同实验室测得的实验曲线吻合良好。

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