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[DNA合成抑制剂对加速重离子作用于哺乳动物细胞的致死效应。理论分析]

[Lethal action of accelerated heavy ions on mammalian cells as affected by inhibitors of DNA synthesis. A theoretical analysis].

作者信息

Kozubek S, Krasavin E A, Govorun R D, Nasonova E A

出版信息

Radiobiologiia. 1987 Mar-Apr;27(2):212-7.

PMID:3575666
Abstract

Günter-Schulz's model and the authors' own model were used to study the dependence of radiosensitivity (D0(-1)) of Chinese hamster cells on linear energy transfer (LET) upon irradiation in standard conditions and in the presence of DNA synthesis inhibitors, arabinosylcytosine and hydroxyurea. A better agreement of the experimental and theoretical results was obtained using Kozubek-Krasavin's model than the model of Günter and Schulz.

摘要

使用京特 - 舒尔茨模型和作者自己的模型来研究中国仓鼠细胞的放射敏感性（D0(-1)）在标准条件下以及存在DNA合成抑制剂阿糖胞苷和羟基脲时对传能线密度（LET）的依赖性。与京特和舒尔茨的模型相比，使用科祖贝克 - 克拉萨文模型能使实验结果和理论结果得到更好的吻合。

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