Zotova E V, Chistiakov D A, Savost'ianov K V, Bursa T R, Galeev I V, Strokov I A, Nosikov V V
State Research Center GosNIIgenetika, Moscow, 117545 Russia.
Mol Biol (Mosk). 2003 May-Jun;37(3):404-8.
Single-nucleotide polymorphisms of the genes for mitochondrial (SOD2) and extracellular (SOD3) superoxide dismutases were tested for association with diabetic polyneuropathy (DPN) in diabetes mellitus (DM) type 1. Patients (n = 180) were divided into two groups with nonoverlapping (polar) phenotypes. Group DPN+ included 86 individuals with DPN and DM type 1 record of no more than 5 years. Group DPN-included 94 patients with DM type 1 record of more than 10 years but without clinical signs of DPN. Fisher's exact test revealed significant differences in allele and genotype frequencies for the two groups. Higher frequencies of SOD2 allele Val and genotype Val/Val and of SOD3 allele Arg and genotype Arg/Arg were established for group DPN+. On this evidence, SOD2 and SOD3 were associated with DPN in DM type 1.
对1型糖尿病患者线粒体超氧化物歧化酶（SOD2）和细胞外超氧化物歧化酶（SOD3）基因的单核苷酸多态性进行检测，以确定其与糖尿病性多发性神经病（DPN）的相关性。患者（n = 180）被分为两组，具有不重叠（两极）表型。DPN+组包括86例患有DPN且1型糖尿病病程不超过5年的个体。DPN-组包括94例1型糖尿病病程超过10年但无DPN临床体征的患者。Fisher精确检验显示两组的等位基因和基因型频率存在显著差异。DPN+组中SOD2基因Val等位基因和Val/Val基因型以及SOD3基因Arg等位基因和Arg/Arg基因型的频率更高。据此证据，SOD2和SOD3与1型糖尿病中的DPN相关。
