[模拟人免疫缺陷病毒gp41（HIV-1）表位的肽段的免疫遗传特性，该表位可被病毒中和抗体2F5识别]
[Immunogenetic properties of peptides mimicking a human immunodeficiency virus gp41 (HIV-1) epitope recognized by virus-neutralizing antibody 2F5].
作者信息
Tumanova O Iu, Kuvshinov V N, Orlovskaia I A, Proniaeva T R, Pokrovskiĭ A G, Il'ichev A A, Sandakhchiev L S
机构信息
Institute of Bioengineering, Vector State Research Center of Virology and Biotechnology, Kol'tsovo, Novosibirsk Oblast, 630559 Russia.
出版信息
Mol Biol (Mosk). 2003 May-Jun;37(3):556-60.
Phage display was used to obtain peptides mimicking a HIV-1 gp41 conserved epitope recognized by virus-neutralizing monoclonal antibodies (MCA) 2F5. Rabbits and mice were immunized with the peptides exposed on the surface of filamentous bacteriophages. Antibodies to gp41 were detected in the sera of immunized animals. The virus-neutralizing activity of the sera was examined.
利用噬菌体展示技术获得模拟被病毒中和单克隆抗体（MCA）2F5识别的HIV-1 gp41保守表位的肽段。用丝状噬菌体表面展示的肽段免疫兔子和小鼠。在免疫动物的血清中检测到针对gp41的抗体。检测了血清的病毒中和活性。
Zotero 插件