Ayangco Lilibeth, Sheridan Phillip J
Periodontics, Department of Dental Specialties, Mayo Clinic, Rochester, MN 55905, USA.
J Periodontol. 2003 May;74(5):669-71. doi: 10.1902/jop.2003.74.5.669.
Minocycline hydrochloride, an analog of tetracycline, is widely used in the treatment of acne. Its use has been associated with discoloration of teeth, bone, and other tissues.
A case is presented involving a patient with minocycline-induced staining of the torus palatinus and alveolar bone.
No treatment was rendered since the patient was not concerned with the appearance of the discoloration. The patient's dermatologist elected to change antibiotics.
Patients on long-term minocycline therapy should be made aware of the possibility of pigmentation of bone and soft tissue that may be reversible with discontinuation of therapy; however, minocycline-induced staining of the permanent dentition may not be reversible.
盐酸米诺环素是四环素的类似物，广泛用于治疗痤疮。其使用与牙齿、骨骼和其他组织的变色有关。
报告一例米诺环素引起的腭隆突和牙槽骨染色患者。
由于患者对变色外观不关心，未进行治疗。患者的皮肤科医生选择更换抗生素。
长期接受米诺环素治疗的患者应了解骨骼和软组织色素沉着的可能性，停药后可能可逆；然而，米诺环素引起的恒牙列染色可能不可逆。
