Friedl Regina, Jackson Thomas, Dinh Thanhphuong, Yoon Thomas Y
School of Dental Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA.
Cureus. 2024 Jul 16;16(7):e64672. doi: 10.7759/cureus.64672. eCollection 2024 Jul.
Minocycline, the synthetic derivative of the antibiotic tetracycline, has been used for a variety of medical treatments. One such use for minocycline is for acne vulgaris. Although widely used, minocycline has a common side effect of discoloration of tissues, including bone, skin, and mucosa. This case report presents a 19-year-old female patient with a history of long-term minocycline therapy for acne vulgaris who presented for periodontal esthetic crown lengthening. The initial exam revealed a blue-gray discoloration of the mucosa. Upon surgical exploration, it was discovered that the discoloration originated from the underlying alveolar bone with minimal gingival involvement. Surgical removal and recontouring of the bony exostoses revealed that the bone remained deeply stained. Although the discolored bone was not fully removed, the patient was able to obtain an acceptable esthetic result.
米诺环素是抗生素四环素的合成衍生物，已被用于多种医学治疗。米诺环素的一种用途是治疗寻常痤疮。尽管米诺环素被广泛使用，但其有一个常见的副作用，即包括骨骼、皮肤和黏膜在内的组织变色。本病例报告介绍了一名19岁女性患者，她有长期使用米诺环素治疗寻常痤疮的病史，前来接受牙周美学牙冠延长术。初次检查发现黏膜呈蓝灰色变色。手术探查发现，变色起源于下方的牙槽骨，牙龈受累最小。对骨外生骨疣进行手术切除和重塑后发现，骨头仍有很深的染色。尽管变色的骨头没有完全切除，但患者能够获得可接受的美学效果。
