A组链球菌M蛋白：毒力因子与保护性抗原
Group A streptococcal M proteins: virulence factors and protective antigens.
作者信息
Robinson J H, Kehoe M A
机构信息
Dept of Immunology, Medical School, University of Newcastle upon Tyne, UK.
出版信息
Immunol Today. 1992 Sep;13(9):362-7. doi: 10.1016/0167-5699(92)90173-5.
PMID:1281632
Abstract
Rebecca Lancefield described group A streptococcal M proteins over 50 years ago, and they have remained at the forefront of investigations into streptococcal pathogenicity to the present day. As described in this review, they form cell surface fibrils with several functions, ranging from resisting phagocytosis and inducing host-crossreactive antibodies, to presenting the host immune system with an accessible protective antigen.
摘要
丽贝卡·兰斯菲尔德在50多年前就描述了A组链球菌的M蛋白，直到如今，它们一直处于链球菌致病性研究的前沿。如本综述所述，它们形成具有多种功能的细胞表面纤维，从抵抗吞噬作用和诱导宿主交叉反应性抗体，到向宿主免疫系统呈递一种易于获取的保护性抗原。
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