Wilkins B S, Williams J H, Kohler J A, Jones D B
Department of Pathology, Southampton General Hospital, United Kingdom.
Pediatr Hematol Oncol. 1992 Oct-Dec;9(4):297-307. doi: 10.3109/08880019209016601.
We performed an immunohistochemical analysis of frozen sections from testicular biopsies from 23 children with acute lymphoblastic leukemia. Eleven cases were infiltrated by leukemia. Tumor cells were immunostained by a panel of antibodies that identified CD10, CD43, CD19, CD3, CD7, and MHC class I and II. The immunoreactivity of normal testicular components was also studied. Normal testis showed no CD10 reactivity. Wide variation in the number of stromal macrophages identified by CD11c was found. Transferrin receptor (CD71) was expressed by some stromal macrophages, by seminiferous tubules, and by Leydig cells. B lymphocytes were absent from the testicular stroma but small numbers of T lymphocytes were consistently present. MHC class I and II were expressed by most stromal cells but not by seminiferous tubules.
我们对23例急性淋巴细胞白血病患儿睾丸活检的冰冻切片进行了免疫组织化学分析。11例存在白血病浸润。肿瘤细胞通过一组可识别CD10、CD43、CD19、CD3、CD7以及MHC I类和II类的抗体进行免疫染色。同时也研究了正常睾丸组织成分的免疫反应性。正常睾丸未显示CD10反应性。发现通过CD11c识别的基质巨噬细胞数量存在广泛差异。转铁蛋白受体（CD71）由一些基质巨噬细胞、生精小管和睾丸间质细胞表达。睾丸基质中不存在B淋巴细胞，但始终存在少量T淋巴细胞。MHC I类和II类由大多数基质细胞表达，但生精小管不表达。
