Wu Lian-fang, Liu Dong-yan, Huang Xing-hua, Zu Xiu-song, Yang Min, Liu Wei-jing, Heng Zong-hua, Chi Xin-zuo, Jia Xiao-fang, Hu Min-hua, Zhao Lian
The Capital University of Medical Sciences, Beijing Obstetrics and Gynecology Hospital, Beijing 100006, China.
Zhonghua Fu Chan Ke Za Zhi. 2003 Mar;38(3):140-2.
To follow up the 75 g oral glucose tolerance test (OGTT) in gestational diabetes mellitus (GDM) at 2 month after birth for reclassifying and analyzing the risk factors associated with the abnormal blood glucose level.
294 cases of GDM underwent a 2 hours 75 g OGTT two months postpartum. According to the WHO diagnostic criteria, they were divided into three groups: (1) type 2 diabetic mellitus (DM), impaired glucose tolerance (IGT) and normal. The related factors during pregnancy were analysed.
160 cases (54.4%) were normal, 75 cases (25.5%) and 59 cases (20.1%) were IGT and DM respectively. (2) In the DM group, the gestational age at diagnosis was much earlier than those of the other two groups (P < 0.01), the glucose level of 50 gram glucose challenge test (GCT) and fasting blood glucose values in OGTT and the value of HbAlc at diagnosis were evidently higher than the other two groups (P < 0.01, P < 0.01, P < 0.01), the gestational age of use of insulin for treatment was earlier than normal group, the dosage used markedly greater than the other two groups, the fasting blood glucose and 2 hours postprandial glucose were significantly higher than other two groups (P < 0.01) within 7 days after birth. Maternal age, body weight and family history did not show difference in the three groups.
Among the GDM, about 1/4 were IGT and 1/5 were type 2 DM. The DM group showed early diagnosis, high fasting blood glucose, high frequency to use insulin during pregnancy.
对妊娠期糖尿病（GDM）患者产后2个月进行75g口服葡萄糖耐量试验（OGTT），以重新分类并分析与血糖水平异常相关的危险因素。
294例GDM患者在产后2个月进行了2小时75g OGTT。根据世界卫生组织诊断标准，将她们分为三组：（1）2型糖尿病（DM）、糖耐量受损（IGT）和正常组。分析孕期相关因素。
160例（54.4%）正常，75例（25.5%）为IGT，59例（20.1%）为DM。（2）DM组诊断时的孕周明显早于其他两组（P<0.01），50g葡萄糖筛查试验（GCT）血糖水平、OGTT空腹血糖值及诊断时糖化血红蛋白（HbAlc）值均明显高于其他两组（P<0.01，P<0.01，P<0.01），使用胰岛素治疗的孕周早于正常组，使用剂量明显大于其他两组，产后7天内空腹血糖和餐后2小时血糖明显高于其他两组（P<0.01）。三组间产妇年龄体重及家族史无差异。
GDM患者中约1/4为IGT，1/5为2型DM。DM组诊断早、空腹血糖高、孕期胰岛素使用频率高。
