一名睾丸癌患者并发副肿瘤性边缘叶脑炎及可能的发作性睡病：病例报告
Paraneoplastic limbic encephalitis and possible narcolepsy in a patient with testicular cancer: case study.
作者信息
Landolfi Joseph C, Nadkarni Mangala
机构信息
New Jersey Neuroscience Institute-JFK Medical Center, 65 James Street, Edison, NJ 08818, USA.
出版信息
Neuro Oncol. 2003 Jul;5(3):214-6. doi: 10.1215/S1152851702000467.
Abstract
We describe a patient who presented with a clinical syndrome of limbic encephalitis, narcolepsy, and cataplexy. The anti-Ma2 antibody was positive. Although there was no mass on imaging, orchiectomy was performed in this patient, and testicular carcinoma was found. This is the first known case of limbic encephalitis and anti-Ma2 antibody to be associated with cataplexy and possible narcolepsy. Neurological symptoms precede the diagnosis of cancer in 50% of patients with paraneoplastic syndromes, and clinicians are therefore strongly advised to evaluate patients with neurological symptoms for this condition.
摘要
我们描述了一名出现边缘性脑炎、发作性睡病和猝倒临床综合征的患者。抗Ma2抗体呈阳性。尽管影像学检查未发现肿块，但该患者接受了睾丸切除术，结果发现患有睾丸癌。这是已知的首例边缘性脑炎和抗Ma2抗体与猝倒及可能的发作性睡病相关的病例。在50%的副肿瘤综合征患者中，神经症状先于癌症诊断出现，因此强烈建议临床医生对有神经症状的患者进行此病的评估。
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