糖尿病肾病的遗传学

Genetics of diabetic nephropathy.

作者信息

Merta M, Reiterova J, Rysavá R, Kmentová D, Tesar V

机构信息

First Medical Department, First Medical Faculty, Charles University, Prague, Czech Republic.

出版信息

Nephrol Dial Transplant. 2003 Jul;18 Suppl 5:v24-5. doi: 10.1093/ndt/gfg1038.

DOI:10.1093/ndt/gfg1038

PMID:12817062

Abstract

Diabetic nephropathy (DN) develops in approximately 40% of type 1 diabetic patients and is a leading cause of end-stage renal failure. Its rate of progression varies greatly among individuals. Several factors, including genetic predisposition, metabolic and haemodynamic alterations and various growth factors, may contribute to the initiation and progression of DN. The genetic background of DN is believed to be polygenic. Polymorphisms of different genes, mainly from the renin-angiotensin system, have been studied extensively, and some of them have been suggested to contribute to the development of DN. A search for genes and combinations of genes which could influence the development and progression of DN is in progress.

摘要

约40%的1型糖尿病患者会发生糖尿病肾病（DN），它是终末期肾衰竭的主要病因。其进展速度在个体间差异很大。包括遗传易感性、代谢和血流动力学改变以及各种生长因子在内的多种因素，可能促使DN的发生和发展。DN的遗传背景被认为是多基因的。不同基因的多态性，主要来自肾素 - 血管紧张素系统，已得到广泛研究，其中一些被认为与DN的发生有关。目前正在寻找可能影响DN发生和发展的基因及基因组合。