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[钙离子和脂肪酸在通过眼镜蛇毒的“直接”溶血素和磷脂酶A抑制Mg2+、Na+和K+-ATP酶中的作用]

[Role of calcium ions and fatty acids in the inhibition of Mg2+, Na+ and K+-ATPases by means of the "direct" hemolysin and phospholipase A of cobra venom].

作者信息

Mirsalikhova N M, Iukel'son L Ia, Ziiamukhamedov R

出版信息

Ukr Biokhim Zh. 1975 Jan-Feb;47(1):61-4.

PMID:128172
Abstract

The influence of calcium ions and fatty acids in the action of direct hemolytic factor and phospholipase A on Mg2+ and Na+, K+-ATPases was investigated. It was established that calcium activates greatly phospholipase A and to a less extent--the direct hemolytic factor. The activity of ATPases is inhibited most effectively by the system consisting of phospholipase A, direct hemolytic factor and Ca2+. Fatty acids can participate in the mechanism of membrane ATPases inhibition.

摘要

研究了钙离子和脂肪酸在直接溶血因子和磷脂酶A对Mg2+和Na+、K+-ATP酶作用中的影响。已确定钙能极大地激活磷脂酶A，对直接溶血因子的激活作用较小。由磷脂酶A、直接溶血因子和Ca2+组成的体系对ATP酶的活性抑制最为有效。脂肪酸可参与膜ATP酶的抑制机制。

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