Lamont S J
Department of Animal Science, Iowa State University, Ames, Iowa 50011-3150, USA.
Poult Sci. 2003 Jun;82(6):882-4. doi: 10.1093/ps/82.6.882.
The ability to answer some of the questions of fundamental interest in functional genetics depends upon the utilization of appropriate and sometimes quite novel population designs. We will explore examples of how unique population designs of varied complexity can be used to explore questions, such as the following. What is the number of genes controlling different biological traits? Can streamlined genetics at the whole-animal level help to dissect complex genetic traits? Are there beneficial alleles "hiding" in undeveloped lines? To what extent is the expression of a specific gene modified by interactions with other genes in the population? Unique genetic resources, combined with novel experimental designs and contemporary analytical techniques, provide exceptional opportunities to explore both fundamental and practical questions in biological sciences.
回答功能遗传学中一些基本感兴趣问题的能力取决于对适当且有时相当新颖的群体设计的运用。我们将探讨不同复杂程度的独特群体设计如何用于探索问题的示例,如下所示。控制不同生物学性状的基因数量是多少?全动物水平的简化遗传学能否有助于剖析复杂的遗传性状?在未开发的品系中是否存在“隐藏”的有益等位基因?群体中一个特定基因的表达在多大程度上会因与其他基因的相互作用而改变?独特的遗传资源,结合新颖的实验设计和当代分析技术,为探索生物科学中的基本问题和实际问题提供了绝佳机会。