Litt R, Seidman D S, Gross-Tsur V, Dollberg S, Gale R
Department of Neonatology, Bikur Holim Hospital, Jerusalem, Israel.
Isr J Med Sci. 1992 Nov;28(11):783-8.
A prospective 2-year follow-up study was carried out on 68 of the 69 surviving very low birthweight (VLBW) infants (< 1,501 g) born in Bikur Holim Hospital in the years 1985-87. The aims were a) to determine the incidence of major disability, and b) to compare the 2-year outcome of VLBW infants without major disability with that of a control group of full-term small-for-gestational-age infants, using the Mental Development Index (MDI) of the Bayley Scales. Mean birthweight of the VLBW infants was 1,234 +/- 216 g and mean gestational age was 30.7 +/- 2.4 weeks. Their neonatal mortality during the study period was 29.8%. Major disability was diagnosed in 11/68 infants (16%). At age 2 years there was no significant difference between the mean MDI of the VLBW infants without major disability (97.7 +/- 19.5) and that of the controls (99.7 +/- 17.0). These data, representing the outcome of VLBW infants from a community-based hospital with neonatal intensive care facilities, are comparable in incidence of major disability with data of large tertiary centers. Cognitive ability of VLBW infants without major disability at age 2 years was equivalent to that of their full-term peers.
对1985 - 1987年在比库尔·霍利姆医院出生的69名存活的极低出生体重（VLBW，<1501克）婴儿中的68名进行了为期2年的前瞻性随访研究。目的是：a）确定严重残疾的发生率；b）使用贝利婴幼儿发展量表的心理发展指数（MDI），比较无严重残疾的极低出生体重婴儿与足月小样儿对照组的2年结局。极低出生体重婴儿的平均出生体重为1234±216克，平均胎龄为30.7±2.4周。研究期间他们的新生儿死亡率为29.8%。68名婴儿中有11名（16%）被诊断为严重残疾。在2岁时，无严重残疾的极低出生体重婴儿的平均MDI（97.7±19.5）与对照组（99.7±17.0）之间无显著差异。这些数据代表了一家设有新生儿重症监护设施的社区医院中极低出生体重婴儿的结局，其严重残疾发生率与大型三级中心的数据相当。2岁时无严重残疾的极低出生体重婴儿的认知能力与其足月同龄人相当。
