FoxP4，一种新型的叉头转录因子。

FoxP4, a novel forkhead transcription factor.

作者信息

Teufel Andreas, Wong Eric A, Mukhopadhyay Mahua, Malik Nasir, Westphal Heiner

机构信息

Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Building 6B, Room 413, 9000 Rockville Pike, Bethesda, MD 20892, USA.

出版信息

Biochim Biophys Acta. 2003 Jun 19;1627(2-3):147-52. doi: 10.1016/s0167-4781(03)00074-5.

DOI:10.1016/s0167-4781(03)00074-5

PMID:12818433

Abstract

Forkhead proteins have been demonstrated to play key roles in embryonic development, cell cycle regulation, and oncogenesis. We report the characterization of a new forkhead transcription factor, which is a member of the FoxP subfamily. In adult tissues FoxP4 is expressed in heart, brain, lung, liver, kidney, and testis. By Northern hybridization, very low levels of FoxP4 expression were found as early as E7 during embryonic development. Embryonic expression was highest at E11 and subsequently decreased at E15 and E17. In situ hybridization revealed expression of FoxP4 in the developing lung and gut, suggesting a role for FoxP4 during the development of these organs. In addition, FoxP4 was found to be significantly reduced in patients with kidney tumors. Lastly, FoxP4 matches an uncharacterized human EST that has previously been shown to be down-regulated in larynx carcinoma.

摘要

叉头蛋白已被证明在胚胎发育、细胞周期调控和肿瘤发生中发挥关键作用。我们报告了一种新的叉头转录因子的特性，它是FoxP亚家族的成员。在成年组织中，FoxP4在心脏、大脑、肺、肝脏、肾脏和睾丸中表达。通过Northern杂交，早在胚胎发育的E7期就发现了极低水平的FoxP4表达。胚胎期表达在E11时最高，随后在E15和E17时下降。原位杂交显示FoxP4在发育中的肺和肠道中表达，提示FoxP4在这些器官的发育过程中发挥作用。此外，在肾肿瘤患者中发现FoxP4明显减少。最后，FoxP4与一个未鉴定的人类EST匹配，该EST先前已被证明在喉癌中下调。