Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Al-Zahra Center for Medical and Pharmaceutical Research Sciences (ZCMRS), Al-Zahraa University for Women, Karbala, Iraq.
J Physiol Biochem. 2024 Aug;80(3):481-499. doi: 10.1007/s13105-024-01022-1. Epub 2024 May 1.
Recent progresses in diagnostic and therapeutic methods have significantly improved prognosis in cancer patients. However, cancer is still considered as one of the main causes of human deaths in the world. Late diagnosis in advanced tumor stages can reduce the effectiveness of treatment methods and increase mortality rate of cancer patients. Therefore, investigating the molecular mechanisms of tumor progression can help to introduce the early diagnostic markers in these patients. MicroRNA (miRNAs) has an important role in regulation of pathophysiological cellular processes. Due to their high stability in body fluids, they are always used as the non-invasive markers in cancer patients. Since, miR-363 deregulation has been reported in a wide range of cancers, we discussed the role of miR-363 during tumor progression and metastasis. It has been reported that miR-363 has mainly a tumor suppressor function through the regulation of transcription factors, apoptosis, cell cycle, and structural proteins. MiR-363 also affected the tumor progression via regulation of various signaling pathways such as WNT, MAPK, TGF-β, NOTCH, and PI3K/AKT. Therefore, miR-363 can be introduced as a probable therapeutic target as well as a non-invasive diagnostic marker in cancer patients.
近年来，诊断和治疗方法的进展显著改善了癌症患者的预后。然而，癌症仍然被认为是世界上人类死亡的主要原因之一。晚期肿瘤阶段的诊断延迟会降低治疗方法的有效性并增加癌症患者的死亡率。因此，研究肿瘤进展的分子机制有助于为这些患者引入早期诊断标志物。微小 RNA（miRNA）在调节生理病理细胞过程中起着重要作用。由于它们在体液中的高度稳定性，它们一直被用作癌症患者的非侵入性标志物。由于 miR-363 在多种癌症中失调已有报道，我们讨论了 miR-363 在肿瘤进展和转移过程中的作用。据报道，miR-363 主要通过调节转录因子、细胞凋亡、细胞周期和结构蛋白来发挥肿瘤抑制功能。miR-363 还通过调节 WNT、MAPK、TGF-β、NOTCH 和 PI3K/AKT 等各种信号通路来影响肿瘤进展。因此，miR-363 可以作为一种可能的治疗靶点和癌症患者的非侵入性诊断标志物。
