Rupprecht Stephan, Merten Hans-Albert, Kessler Peter, Wiltfang Jörg
Department of Oral & Cranio-Maxillofacial Surgery, Erlangen-Nuremberg University, Glueckstr 11, Erlangen, Germany.
J Craniomaxillofac Surg. 2003 Jun;31(3):149-53. doi: 10.1016/s1010-5182(03)00017-9.
In an experimental study the hydroxyapatite cement BoneSource was tested for the ability in relation to the defect size and for its resorption properties.
In an animal study, BoneSource was applied to repair bicortical defects of different sizes in frontal bones of six Goettingen minipigs. The area was evaluated radiographically and histologically 12, 18 and 40 weeks postoperatively.
After 40 weeks approximately 90% of the hydroxyapatite cement had been resorbed and replaced with bone. After 12 weeks, approximately 30% had been degraded, and 40% after 18 weeks. In small bone defects, the mucosa of the frontal sinus lined the bone substitute (BoneSource). In the reconstruction of large areas, a membrane was used to stabilize the material. Despite this membranous support, BoneSource material prolapsed into the frontal sinus.
Hydroxyapatite cement is for the repair of bone defects. It can be moulded to shape the reconstruction. Its use is limited by the defect size and the need for a dry bed.
BoneSource is well suited to repair small defects with proven high biocompatibility. However, in large defects, the material is not sufficiently stable.
在一项实验研究中，对羟基磷灰石骨水泥BoneSource修复骨缺损的能力及其吸收特性进行了测试。
在一项动物研究中，将BoneSource应用于修复6只哥廷根小型猪额骨不同大小的双侧皮质骨缺损。术后12周、18周和40周对该区域进行影像学和组织学评估。
40周后，约90%的羟基磷灰石骨水泥已被吸收并被骨组织替代。12周后，约30%已降解，18周后为40%。在小骨缺损中，额窦黏膜覆盖在骨替代物（BoneSource）上。在大面积重建中，使用了一张膜来稳定材料。尽管有这种膜性支撑，BoneSource材料仍脱垂至额窦内。
羟基磷灰石骨水泥适用于修复骨缺损。它可以塑形以进行重建。其应用受到缺损大小和需要干燥床的限制。
BoneSource非常适合修复小缺损，具有已证实的高生物相容性。然而，在大缺损中，该材料稳定性不足。
