Radi A
Department of Chemistry, Faculty of Science, Mansoura University, 34517 Dumyat, Egypt.
Farmaco. 2003 Jul;58(7):535-9. doi: 10.1016/S0014-827X(03)00082-X.
A voltammetric method was described for the determination of pantoprazole by differential-pulse adsorptive stripping voltammetry at a carbon paste electrode. Accumulation of pantoprazole was found to be optimized in Britton-Robinson buffer (0.04 M, pH 4.0) solution following 5 min accumulation time at open circuit condition. Under optimized conditions, the current showed a linear dependence with concentration in the range 1.0 x 10(-7)-1.0 x 10(-5) M. The detection limit was 2.0 x 10(-8) M. The method was applied successfully for the analysis of pantoprazole in tablet dosage form. The results of accuracy and precision were comparable to those obtained by spectrophotometry.
描述了一种通过差分脉冲吸附溶出伏安法在碳糊电极上测定泮托拉唑的伏安法。发现在开路条件下在Britton-Robinson缓冲液（0.04 M，pH 4.0）溶液中积累5分钟后，泮托拉唑的积累效果最佳。在优化条件下，电流与浓度在1.0×10⁻⁷ - 1.0×10⁻⁵ M范围内呈线性关系。检测限为2.0×10⁻⁸ M。该方法成功应用于片剂剂型中泮托拉唑的分析。准确度和精密度结果与分光光度法所得结果相当。
