Khashaba Pakinaz Y, Ali Hassan Refat H, El-Wekil Mohamed M
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Deraya University, El-Minya, Egypt.
R Soc Open Sci. 2017 Aug 9;4(8):170324. doi: 10.1098/rsos.170324. eCollection 2017 Aug.
A pencil graphite electrode modified with poly (bromocresol green (BCG)) was prepared by electro-polymerization process for the determination of pantoprazole sodium. The surface morphology and structure of poly (BCG) film were characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. The determination of pantoprazole sodium in Britton-Robinson buffer (pH 7.0) was carried out by square wave adsorptive stripping voltammetric technique. Under optimum conditions, the linear response of the peak with concentration of the cited drug was in the range of 6.6-360 × 10M with limit of detection of 2.2 × 10M. Moreover, the poly (BCG)-modified electrode has been successfully applied to determine pantoprazole sodium in tablets, vials and during pharmacokinetic studies.
通过电聚合过程制备了一种用聚（溴甲酚绿（BCG））修饰的铅笔石墨电极，用于泮托拉唑钠的测定。采用扫描电子显微镜和傅里叶变换红外光谱对聚（BCG）膜的表面形貌和结构进行了表征。在 Britton-Robinson 缓冲液（pH 7.0）中，采用方波吸附溶出伏安法测定泮托拉唑钠。在最佳条件下，所测药物的峰电流与浓度呈线性响应，线性范围为 6.6 - 360×10⁻⁶ M，检测限为 2.2×10⁻⁶ M。此外，聚（BCG）修饰电极已成功应用于片剂、小瓶及药代动力学研究中泮托拉唑钠的测定。
