长链多不饱和脂肪酸对高苯丙氨酸血症儿童的长期影响。
Long term effects of long chain polyunsaturated fats in hyperphenylalaninemic children.
作者信息
Agostoni C, Verduci E, Massetto N, Fiori L, Radaelli G, Riva E, Giovannini M
机构信息
Department of Pediatrics, San Paolo Hospital, University of Milan, Milan, Italy.
出版信息
Arch Dis Child. 2003 Jul;88(7):582-3. doi: 10.1136/adc.88.7.582.
Abstract
Blood fatty acid status and visual function of 20 treated hyperphenylalaninemic (HPA) children, randomly allocated into two groups to receive supplementation of either long chain polyunsaturated fatty acids (LCPUFA), including docosahexaenoic acid (DHA), or placebo for 12 months, have been investigated three years after the end of the treatment. Although in the LCPUFA group blood DHA levels and P100 wave latency improved at the end of supplementation, they had returned to baseline after three years.
摘要
对20名接受治疗的高苯丙氨酸血症（HPA）儿童的血液脂肪酸状况和视觉功能进行了研究。这些儿童被随机分为两组，一组接受包括二十二碳六烯酸（DHA）在内的长链多不饱和脂肪酸（LCPUFA）补充剂，另一组接受安慰剂，为期12个月。治疗结束三年后进行了调查。虽然在LCPUFA组中，补充剂结束时血液DHA水平和P100波潜伏期有所改善，但三年后它们又回到了基线水平。
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