《自闭症诊断访谈修订版》的主成分分析
A principal components analysis of the Autism Diagnostic Interview-Revised.
作者信息
Tadevosyan-Leyfer Ovsanna, Dowd Michael, Mankoski Raymond, Winklosky Brian, Putnam Sara, McGrath Lauren, Tager-Flusberg Helen, Folstein Susan E
机构信息
Department of Psychiatry, Tufts New England Medical Center, Boston, MA, USA.
出版信息
J Am Acad Child Adolesc Psychiatry. 2003 Jul;42(7):864-72. doi: 10.1097/01.CHI.0000046870.56865.90.
OBJECTIVE
To develop factors based on the Autism Diagnostic Interview-Revised (ADI-R) that index separate components of the autism phenotype that are genetically relevant and validated against standard measures of the constructs.
METHOD
ADIs and ADI-Rs of 292 individuals with autism were subjected to a principal components analysis using VARCLUS. The resulting variable clusters were validated against standard measures.
RESULTS
Six clusters of variables emerged: spoken language, social intent, compulsions, developmental milestones, savant skills and sensory aversions. Five of the factors were significantly correlated with the validating measures and had good internal consistency, face validity, and discriminant and construct validity. Most intraclass correlations between siblings were adequate for use in genetic studies.
CONCLUSION
The ADI-R contains correlated clusters of variables that are valid, genetically relevant, and that can be used in a variety of studies.
目的
基于修订版自闭症诊断访谈量表（ADI-R）开发一些因素，用以索引自闭症表型中与基因相关的不同组成部分，并根据这些结构的标准测量方法进行验证。
方法
对292名自闭症患者的ADI和ADI-R进行主成分分析，采用VARCLUS法。将所得的变量聚类与标准测量方法进行验证。
结果
出现了六个变量聚类：口语、社交意图、强迫行为、发育里程碑、学者技能和感觉厌恶。其中五个因素与验证测量方法显著相关，具有良好的内部一致性、表面效度、判别效度和结构效度。兄弟姐妹之间的大多数组内相关系数适用于基因研究。
结论
ADI-R包含相互关联的变量聚类，这些聚类有效、与基因相关，可用于各种研究。
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