阿尔茨海默病中海马结构中含一氧化氮合酶神经元的相对保留

Relative sparing of nitric oxide synthase-containing neurons in the hippocampal formation in Alzheimer's disease.

作者信息

Hyman B T, Marzloff K, Wenniger J J, Dawson T M, Bredt D S, Snyder S H

机构信息

Neurology Service, Massachusetts General Hospital, Boston 02114.

出版信息

Ann Neurol. 1992 Dec;32(6):818-20. doi: 10.1002/ana.410320618.

DOI:10.1002/ana.410320618

PMID:1281971

Abstract

Nitric oxide (NO) is an endogenous neuromodulator that may mediate neurotoxic effects of glutamate. NO-synthesizing neurons are, however, resistant to NO- and glutamate-induced neurotoxicity. We now show that NO synthase neurons are selectively spared in patients with Alzheimer's disease, even in a severely affected region of the brain such as the hippocampal formation.

摘要

一氧化氮（NO）是一种内源性神经调节剂，可能介导谷氨酸的神经毒性作用。然而，合成NO的神经元对NO和谷氨酸诱导的神经毒性具有抗性。我们现在表明，在阿尔茨海默病患者中，即使在大脑严重受影响的区域，如海马结构，合成NO合酶的神经元也能选择性地幸免。