Davenport M, Rivlin E, D'Souza S W, Bianchi A
Regional Neonatal Surgical Unit, St Mary's Hospital, Manchester.
Arch Dis Child. 1992 Nov;67(11):1353-6. doi: 10.1136/adc.67.11.1353.
The long term neurodevelopmental outcome was assessed in 23 survivors born with congenital diaphragmatic hernia who had been managed by an elective delay in surgical repair after a period of stabilisation. This cohort was treated in one neonatal surgical unit between 1983 and 1989 by a single team of surgeons and anaesthetists. All children underwent comprehensive neurological, developmental, and anthropometric assessment at a mean age of 56 (range 18-94) months. Two children (9%) had major disability (one with hemiplegia and one with a lower limb monoplegia) and two further children had minor disabilities (one had partial sightedness and squint, the other squint only). The mean developmental quotient (DQ) for the group was 108 (SD 10.8) and none had developmental delay (defined as DQ < 70). Infants who had spent more time in hospital, or had had a longer duration of ventilation, tended to have lower weights and lower occipitofrontal circumference centiles in later childhood. Preoperative stabilisation and delayed surgery for congenital diaphragmatic hernia is not associated with an impaired neurodevelopmental outcome.
对23例先天性膈疝存活患儿的长期神经发育结局进行了评估,这些患儿在经过一段时间的稳定期后接受了择期延迟手术修复治疗。该队列患儿于1983年至1989年在一个新生儿外科病房由一组外科医生和麻醉师进行治疗。所有儿童在平均年龄56(范围18 - 94)个月时接受了全面的神经、发育和人体测量评估。两名儿童(9%)有严重残疾(一名偏瘫,一名下肢单瘫),另有两名儿童有轻度残疾(一名有部分视力和斜视,另一名仅有斜视)。该组儿童的平均发育商(DQ)为108(标准差10.8),且无发育迟缓(定义为DQ < 70)。住院时间较长或通气时间较长的婴儿在儿童后期往往体重较低,枕额周长百分位数也较低。先天性膈疝的术前稳定和延迟手术与神经发育结局受损无关。