Calvert S A, Hoskins E M, Fong K W, Forsyth S C
Acta Paediatr Scand. 1987 Mar;76(2):254-9. doi: 10.1111/j.1651-2227.1987.tb10456.x.
Prenatal, intrapartum and postnatal factors are compared between 15 preterm infants, known to have periventricular leukomalacia (PVL) on ultrasound and 15 infants of similar birthweight and gestation who ultrasonographically showed no evidence of cystic lesions, and who are known to be neurologically normal at follow up. Prenatally, the incidence of antepartum haemorrhage was significantly higher in the PVL group. Intrapartum factors were similar between the two groups but postnatally, the PVL group had significantly lower PaCO2 readings during the first 72 h of life. It is postulated that a severe maternal bleed in late pregnancy and neonatal hypocarbia could significantly decrease cerebral perfusion and cause areas of ischaemia and infarction resulting in periventricular leukomalacia.
对15例经超声检查确诊为脑室周围白质软化（PVL）的早产儿与15例出生体重和孕周相似、超声检查未显示囊性病变证据且随访时神经功能正常的婴儿的产前、产时和产后因素进行了比较。产前，PVL组产前出血的发生率显著更高。两组的产时因素相似，但产后，PVL组在出生后72小时内的PaCO2读数显著更低。据推测，妊娠晚期严重的母体出血和新生儿低碳酸血症可能会显著降低脑灌注，导致缺血和梗死区域，从而引起脑室周围白质软化。
