Hess David, Li Li, Martin Matthew, Sakano Seiji, Hill David, Strutt Brenda, Thyssen Sandra, Gray Douglas A, Bhatia Mickie
Robarts Research Institute, Stem Cell Biology and Regenerative Medicine, 100 Perth Drive, London, Ontario N6A 5K8, Canada.
Nat Biotechnol. 2003 Jul;21(7):763-70. doi: 10.1038/nbt841. Epub 2003 Jun 22.
We show that transplantation of adult bone marrow-derived cells expressing c-kit reduces hyperglycemia in mice with streptozotocin-induced pancreatic damage. Although quantitative analysis of the pancreas revealed a low frequency of donor insulin-positive cells, these cells were not present at the onset of blood glucose reduction. Instead, the majority of transplanted cells were localized to ductal and islet structures, and their presence was accompanied by a proliferation of recipient pancreatic cells that resulted in insulin production. The capacity of transplanted bone marrow-derived stem cells to initiate endogenous pancreatic tissue regeneration represents a previously unrecognized means by which these cells can contribute to the restoration of organ function.
我们发现，移植表达c-kit的成年骨髓源细胞可降低链脲佐菌素诱导的胰腺损伤小鼠的高血糖水平。尽管对胰腺的定量分析显示供体胰岛素阳性细胞的频率较低，但在血糖降低开始时这些细胞并不存在。相反，大多数移植细胞定位于导管和胰岛结构，它们的存在伴随着受体胰腺细胞的增殖，从而导致胰岛素产生。移植的骨髓源干细胞启动内源性胰腺组织再生的能力代表了一种以前未被认识的这些细胞有助于恢复器官功能的方式。
