Frisch I B, Völcker H E, Dithmar S
Universitäts-Augenklinik Heidelberg.
Ophthalmologe. 2003 Jun;100(6):476-8. doi: 10.1007/s00347-003-0819-x.
Nevi arise from migration of melanocytes into the epithelium. Over the years they experience a typical maturation, with the possibility of an increased thickness due to accompanying inflammation or fibrosis but actual growth of nevi is rare in adults. A 70-year-old patient presented with a growing tumour around the punctum lacrimale. The histological examination revealed a conjunctival nevus without any transformation. Peripunctal nevi are rare. The localisation of a nevus in the area of the punctum lacrimale was first published in 1931 and only 10 other patients with such a nevus have been reported. If at all, an enlargement of a peripunctal nevus has been described in younger patients. The patient presented here showed significant growth of the nevus at an atypically high age without any histological signs of malignancy or proliferation. The reason for this uncommon nevus enlargement remains unclear.
痣起源于黑素细胞迁移至上皮组织。多年来,它们经历典型的成熟过程,可能因伴随的炎症或纤维化而增厚,但成年人中痣的实际生长情况很少见。一名70岁患者的泪小点周围出现了一个不断增大的肿瘤。组织学检查显示为结膜痣,无任何恶变迹象。泪小点周围的痣很少见。痣位于泪小点区域的情况最早于1931年发表,此后仅报告了另外10例有此类痣的患者。如果有,泪小点周围痣的增大仅在年轻患者中被描述过。此处呈现的患者在非典型的高龄时痣显著增大,且无任何恶性或增殖的组织学迹象。这种不常见的痣增大的原因尚不清楚。