Zhang Geoff G Z, Paspal Sophia Y L, Suryanarayanan Raj, Grant David J W
Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Weaver-Densford Hall, 308 Harvard Street Southeast, Minneapolis, MN 55455-0343, USA.
J Pharm Sci. 2003 Jul;92(7):1356-66. doi: 10.1002/jps.10393.
Racemic and homochiral sodium ibuprofen were characterized by thermal analysis and powder X-ray diffractometry. The melting point phase diagram was constructed and thermodynamic calculation was performed. In contrast to racemic ibuprofen, which is a racemic compound, racemic sodium ibuprofen forms both a racemic conglomerate (termed the gamma-form) as well as two polymorphic racemic compounds, alpha and beta, which are less stable monotropes. From the supercooled liquid, alpha and beta crystallized along with the original gamma-form. Forms alpha and beta are "enantiotropically related" with a transition temperature between 75 degrees and 113 degrees C, but can be considered to be metastable monotropes of the racemic conglomerate, the stable gamma-form.
通过热分析和粉末X射线衍射法对消旋和纯手性布洛芬钠进行了表征。构建了熔点相图并进行了热力学计算。与作为外消旋化合物的消旋布洛芬不同，消旋布洛芬钠形成了一种外消旋聚集体（称为γ型）以及两种多晶型外消旋化合物α和β，它们是不太稳定的单向变体。从过冷液体中，α和β与原始的γ型一起结晶。α和β型在75摄氏度至113摄氏度之间具有转变温度，呈“对映变体关系”，但可被视为外消旋聚集体（稳定的γ型）的亚稳单向变体。
