Leising G, Resel R, Stelzer F, Tasch S, Lanziner A, Hantich G
Institut für Festkörperphysik, Technische Universität Graz, Austria.
J Clin Pharmacol. 1996 Dec;36(12 Suppl):3S-6S.
This article presents a comparative study of ibuprofen materials in their solid state. Ibuprofen crystallizes into two different structures for the S(+) enantiomer (dexibuprofen) and racemic ibuprofen. The crystal structure of ibuprofen, its optical absorption and photoluminescence, and the thermodynamic results (melting point and heat of fusion) are discussed. From these physicochemical properties, the authors conclude that dexibuprofen, which is the most active species pharmaceutically, and racemic ibuprofen are inherently different solid-state materials.
本文介绍了布洛芬材料固态的比较研究。S(+)对映体（右旋布洛芬）和外消旋布洛芬的布洛芬结晶成两种不同的结构。讨论了布洛芬的晶体结构、光吸收和光致发光以及热力学结果（熔点和熔化热）。从这些物理化学性质来看，作者得出结论，作为药学上最具活性的物种，右旋布洛芬和外消旋布洛芬本质上是不同的固态材料。
