Sadraei H, Asghari G, Naddafi A
Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Phytother Res. 2003 Jun;17(6):645-9. doi: 10.1002/ptr.1217.
Pycnocycla spinosa is an essential oil from a wild plant growing in central Iran. However, so far its pharmacological effects have not been studied. The aim of this study was to look for relaxant effects of the essential oil and hydro-alcoholic extract of P. spinosa on rat isolated ileum contractions induced by KCl and acetylcholine (ACh). P. spinosa essential oil (PSEO) and the hydro-alcoholic extract inhibited the response to 80 mM KCl in a concentration-dependent manner and attenuated the maximum attainable response of ACh concentration-response curve. Furthermore, in caster oil induced diarrhoea, the hydro-alcoholic extract had a dose-dependent anti-diarrhoeal effect. This study showed that P. spinosa essential oil and its hydro-alcoholic extract act as a relaxant of rat isolated ileum. As the inhibition of contractile over-activity of the ileum is the basis for the treatment of gastro-intestinal disorders such as diarrhoea, P. spinosa may have clinical bene fi ts for treatment of this condition.
刺环菊是一种源自生长于伊朗中部野生植物的精油。然而，迄今为止其药理作用尚未得到研究。本研究的目的是探寻刺环菊精油和水醇提取物对氯化钾（KCl）和乙酰胆碱（ACh）诱导的大鼠离体回肠收缩的松弛作用。刺环菊精油（PSEO）和水醇提取物以浓度依赖性方式抑制对80 mM KCl的反应，并减弱ACh浓度-反应曲线的最大可达到反应。此外，在蓖麻油诱导的腹泻中，水醇提取物具有剂量依赖性止泻作用。本研究表明，刺环菊精油及其水醇提取物可作为大鼠离体回肠的松弛剂。由于抑制回肠的收缩过度活动是治疗腹泻等胃肠道疾病的基础，刺环菊可能对治疗这种疾病具有临床益处。
