Wittrup Minna, Pildal Julie, Rasmussen Ase Krogh, Skov Birgit Guldhammer, Petersen Jørgen, Mandrup-Poulsen Thomas R
Steno Diabetes Center, Gentofte.
Ugeskr Laeger. 2003 May 19;165(21):2207-8.
After introduction of recombinant human insulin, immunological reactions have become rare, but symptomatic immune reactions to insulin still occur. We present four insulin-treated diabetic patients who developed hypersensitivity to insulin or additives to insulin preparations. We show that symptomatic immunological reactions to insulin have not been eliminated by the introduction of recombinant human insulin. Furthermore it demonstrates the importance of skin-biopsy-verified diagnoses and the relevance of differentiation between different types of insulin allergy.
在重组人胰岛素引入后，免疫反应已变得罕见，但对胰岛素的症状性免疫反应仍会发生。我们报告了4例接受胰岛素治疗的糖尿病患者，他们对胰岛素或胰岛素制剂中的添加剂产生了超敏反应。我们发现，重组人胰岛素的引入并未消除对胰岛素的症状性免疫反应。此外，这还证明了经皮肤活检证实的诊断的重要性以及区分不同类型胰岛素过敏的相关性。
