Obara Daiji, Nagane Yuriko, Utsugisawa Kimiaki, Kondoh Ryushi, Tohgi Hideo
Department of Neurology, Iwate Medical University.
Rinsho Shinkeigaku. 2003 Jan-Feb;43(1-2):38-40.
A 59-year-old man developed progressive sensory dullness and muscle weakness in the extremities, facial palsy on the left side, and hoarseness 4 days after the onset of acute hepatitis A. Vibration and joint sensation in the extremities were severely affected. Anti-sulfatide IgM antibody level was initially elevated in serum, but diminished along with amelioration of the symptoms following intravenous immunoglobulin therapy. Anti-sulfatide antibody may be involved in the pathogenesis of the present patient with hepatitis A-associated Guillain-Barré syndrome. This is probably the first case of hepatitis A associated Guillain-Barré syndrome with which elevated serum anti-sulfatide antibody was found.
一名59岁男性在甲型肝炎发病4天后出现四肢进行性感觉迟钝和肌肉无力、左侧面瘫及声音嘶哑。四肢的振动觉和关节觉严重受损。血清中抗硫脂IgM抗体水平最初升高，但在静脉注射免疫球蛋白治疗后随症状改善而降低。抗硫脂抗体可能参与了本例甲型肝炎相关格林-巴利综合征患者的发病机制。这可能是首例发现血清抗硫脂抗体升高的甲型肝炎相关格林-巴利综合征病例。
