病例报告：甲型肝炎先于吉兰-巴雷综合征出现。

Case report: Hepatitis A preceding Guillain-Barré syndrome.

作者信息

Chitambar Shobha D, Fadnis Rahul S, Joshi Madhuri S, Habbu A, Bhatia S G

机构信息

National Institute of Virology, Pune, Maharashtra, India.

出版信息

J Med Virol. 2006 Aug;78(8):1011-4. doi: 10.1002/jmv.20656.

DOI:10.1002/jmv.20656

PMID:16789022

Abstract

A case of acute hepatitis A with Guillain-Barré Syndrome subtype AMAN (acute motor axonal neuropathy) in a 17-year-old male is reported. Serum and cerebrospinal fluid were positive for anti-hepatitis A virus (HAV) IgM, IgG, and IgA. The onset of the syndrome was evident in week 3 of illness. The remarkably high titers of serum anti-HAV IgG appeared unique to a hepatitis A patient with the syndrome. Phylogenetic analysis of the HAV genome detected in the serum and feces revealed genotype IIIA, circulating commonly in Pune, western India.

摘要

报告了一例17岁男性患急性甲型肝炎合并格林-巴利综合征亚型AMAN（急性运动轴索性神经病）的病例。血清和脑脊液中的抗甲型肝炎病毒（HAV）IgM、IgG和IgA呈阳性。该综合征在发病第3周明显出现。血清抗HAV IgG的高滴度在患有该综合征的甲型肝炎患者中显得独特。对血清和粪便中检测到的HAV基因组进行系统发育分析，发现为IIIA基因型，在印度西部浦那普遍流行。