海胆去纤毛作用诱导耐热性并激活p38丝裂原活化蛋白激酶途径。
Sea urchin deciliation induces thermoresistance and activates the p38 mitogen-activated protein kinase pathway.
作者信息
Casano Caterina, Roccheri Maria Carmela, Maenza Luisa, Migliore Silvia, Gianguzza Fabrizio
机构信息
Dipartimento di Biologia Cellulare e dello Sviluppo "A. Monroy," Università di Palermo, Viale delle Scienze, Parco D'Orleans, 90128 Palermo, Italy.
出版信息
Cell Stress Chaperones. 2003 Spring;8(1):70-5. doi: 10.1379/1466-1268(2003)8<70:sudita>2.0.co;2.
Abstract
In this study, we demonstrate by a variety of approaches (ie, morphological analysis, Western blots, immunolocalization, and the use of specific antibodies) that hyperosmotic deciliation stress of sea urchin embryos induces a thermotolerant response. Deciliation is also able to activate a phosphorylation signaling cascade the effector of which might be the p38 stress-activated protein kinase because we found that the administration of the p38 inhibitor SB203580 to sea urchin deciliated gastrula embryos makes the hyperosmotic deciliation stress lethal.
摘要
在本研究中，我们通过多种方法（即形态学分析、蛋白质免疫印迹、免疫定位以及使用特异性抗体）证明，海胆胚胎的高渗去纤毛应激可诱导耐热反应。去纤毛还能够激活磷酸化信号级联反应，其效应器可能是p38应激激活蛋白激酶，因为我们发现，向海胆去纤毛原肠胚胚胎施用p38抑制剂SB203580会使高渗去纤毛应激变得致命。
相似文献
1
Sea urchin deciliation induces thermoresistance and activates the p38 mitogen-activated protein kinase pathway.海胆去纤毛作用诱导耐热性并激活p38丝裂原活化蛋白激酶途径。
Cell Stress Chaperones. 2003 Spring;8(1):70-5. doi: 10.1379/1466-1268(2003)8<70:sudita>2.0.co;2.
2
Deciliation: A stressful event for Paracentrotus lividus embryos.
Biochem Biophys Res Commun. 1998 Jul 30;248(3):628-34. doi: 10.1006/bbrc.1998.9032.
3
Stimulation of tubulin gene transcription by deciliation of sea urchin embryos.海胆胚胎去纤毛作用对微管蛋白基因转录的刺激
Mol Cell Biol. 1987 Dec;7(12):4238-46. doi: 10.1128/mcb.7.12.4238-4246.1987.
4
Inhibition of mitogen activated protein kinase signaling affects gastrulation and spiculogenesis in the sea urchin embryo.有丝分裂原活化蛋白激酶信号传导的抑制会影响海胆胚胎的原肠胚形成和骨针发生。
Dev Growth Differ. 2003 Oct-Dec;45(5-6):527-42. doi: 10.1111/j.1440-169x.2003.00710.x.
5
Stimulation of MAPK cascades by insulin and osmotic shock: lack of an involvement of p38 mitogen-activated protein kinase in glucose transport in 3T3-L1 adipocytes.胰岛素和渗透压休克对丝裂原活化蛋白激酶（MAPK）级联反应的刺激：p38丝裂原活化蛋白激酶不参与3T3-L1脂肪细胞的葡萄糖转运
Diabetes. 2000 Nov;49(11):1783-93. doi: 10.2337/diabetes.49.11.1783.
6
7
Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase.G蛋白偶联受体激动剂使成年大鼠心肌细胞中的丝裂原和应激激活蛋白激酶-1发生磷酸化并激活，这需要细胞外信号调节激酶和p38丝裂原活化蛋白激酶两者的参与。
Biochem J. 2002 Aug 1;365(Pt 3):757-63. doi: 10.1042/BJ20011828.
8
Cytosolic phospholipase A2 activation by the p38 kinase inhibitor SB203580 in rabbit aortic smooth muscle cells.p38激酶抑制剂SB203580在兔主动脉平滑肌细胞中激活胞质磷脂酶A2
J Pharmacol Exp Ther. 2001 Jul;298(1):331-8.
9
Modulation of renal epithelial barrier function by mitogen-activated protein kinases (MAPKs): mechanism of cyclosporine A-induced increase in transepithelial resistance.丝裂原活化蛋白激酶（MAPKs）对肾上皮屏障功能的调节：环孢素A诱导跨上皮电阻增加的机制
Kidney Int. 2003 Mar;63(3):908-16. doi: 10.1046/j.1523-1755.2003.00804.x.
10
Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway.应激诱导的信号转导和转录激活因子1（STAT1）在丝氨酸727位点的磷酸化需要p38丝裂原活化蛋白激酶，而γ干扰素则使用不同的信号通路。
Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13956-61. doi: 10.1073/pnas.96.24.13956.
引用本文的文献
1
Assessment and Monitoring of Fish Quality from a Coastal Ecosystem under High Anthropic Pressure: A Case Study in Southern Italy.沿海生态系统在高强度人为压力下的鱼类质量评估和监测：意大利南部的一个案例研究。
Int J Environ Res Public Health. 2020 May 8;17(9):3285. doi: 10.3390/ijerph17093285.
2
Toxic Diatom Aldehydes Affect Defence Gene Networks in Sea Urchins.有毒硅藻醛影响海胆的防御基因网络。
PLoS One. 2016 Feb 25;11(2):e0149734. doi: 10.1371/journal.pone.0149734. eCollection 2016.
3
Cadmium induces an apoptotic response in sea urchin embryos.镉会在海胆胚胎中引发凋亡反应。
Cell Stress Chaperones. 2007 Spring;12(1):44-50. doi: 10.1379/csc-229r.1.
本文引用的文献
1
Localization of mitochondrial Hsp56 chaperonin during sea urchin development.海胆发育过程中线粒体Hsp56伴侣蛋白的定位
Biochem Biophys Res Commun. 2001 Oct 12;287(5):1093-8. doi: 10.1006/bbrc.2001.5503.
2
Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli.热休克蛋白27可保护耐热细胞的线粒体免受凋亡刺激。
Cell Stress Chaperones. 2001 Jan;6(1):49-58. doi: 10.1379/1466-1268(2001)006<0049:hpmotc>2.0.co;2.
3
Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27.蛋白激酶抑制剂可以抑制应激诱导的Hsp27解离。
Cell Stress Chaperones. 2001 Jan;6(1):16-20. doi: 10.1379/1466-1268(2001)006<0016:pkicss>2.0.co;2.
4
Stress management - heat shock protein-70 and the regulation of apoptosis.应激管理——热休克蛋白70与细胞凋亡的调控
Trends Cell Biol. 2001 Jan;11(1):6-10. doi: 10.1016/s0962-8924(00)01874-2.
5
EGTA treatment causes the synthesis of heat shock proteins in sea urchin embryos.
Mol Cell Biol Res Commun. 2000 May;3(5):306-11. doi: 10.1006/mcbr.2000.0230.
6
Response of Saccharomyces cerevisiae to severe osmotic stress: evidence for a novel activation mechanism of the HOG MAP kinase pathway.酿酒酵母对严重渗透胁迫的响应：HOG丝裂原活化蛋白激酶途径新激活机制的证据
Mol Microbiol. 2000 Jul;37(2):382-97. doi: 10.1046/j.1365-2958.2000.02002.x.
7
The mitogen-activated protein kinase p38 pathway is conserved in metazoans: cloning and activation of p38 of the SAPK2 subfamily from the sponge Suberites domuncula.有丝分裂原活化蛋白激酶p38信号通路在多细胞动物中是保守的：从海绵动物Suberites domuncula克隆并激活SAPK2亚家族的p38。
Biol Cell. 2000 Apr;92(2):95-104. doi: 10.1016/s0248-4900(00)89017-6.
8
p38 MAPK signalling cascades: ancient roles and new functions.p38丝裂原活化蛋白激酶信号级联反应：古老的作用与新功能
Bioessays. 2000 Jul;22(7):637-45. doi: 10.1002/1521-1878(200007)22:7<637::AID-BIES6>3.0.CO;2-E.
9
p38 MAP kinases: beyond the stress response.p38丝裂原活化蛋白激酶：超越应激反应
Trends Biochem Sci. 2000 Jun;25(6):257-60. doi: 10.1016/s0968-0004(00)01595-4.
10
Heat shock proteins: regulators of stress response and apoptosis.热休克蛋白：应激反应和细胞凋亡的调节因子。
Cell Stress Chaperones. 1998 Dec;3(4):228-36. doi: 10.1379/1466-1268(1998)003<0228:hspros>2.3.co;2.
Zotero 插件