Qian J Q, Huang S F
Department of Pathology, Beijing Friendship Hospital.
Zhonghua Bing Li Xue Za Zhi. 1992 Aug;21(4):198-201.
A series of 56 cases of prostatic adenocarcinoma and 48 cases of benign prostate hyperplasia were studied with histochemical, immunohistochemical methods and Feulgen-Image Analysis Technique. Duct-acinar dysplasia (DAD) was found in 81.8% of the prostate adenocarcinoma cases collected, but only in 47.9% of the benign hyperplasia cases. The frequency and extent of disruption of basal cell layer increased coincidently with the progressive increase of DAD grading. Intraluminal acid mucin and metachromasia stained with toluidine blue around the acini were identified in DAD. Immunohistochemical staining for prostatic acid phosphatase, cytokeratin, vimentin and UEA-1 receptor changed in DAD cells. The nuclear areas, DNA content and ploidy, mean numbers of AgNOR in DAD cells were higher than those in benign hyperplasia of the prostates and lower than those in adenocarcinomas, which indicates the possession of premalignant behavior of prostatic carcinoma.
采用组织化学、免疫组织化学方法及Feulgen图像分析技术对56例前列腺腺癌和48例良性前列腺增生病例进行了研究。在所收集的前列腺腺癌病例中，81.8%发现有腺泡发育异常（DAD），而在良性增生病例中仅为47.9%。基底细胞层破坏的频率和程度随DAD分级的逐渐增加而同步增加。在DAD中可识别出腺泡内的酸性粘蛋白以及腺泡周围经甲苯胺蓝染色的异染性。DAD细胞中前列腺酸性磷酸酶、细胞角蛋白、波形蛋白和UEA-1受体的免疫组织化学染色发生改变。DAD细胞的核面积、DNA含量和倍体、核仁组成区嗜银蛋白平均数量高于前列腺良性增生，低于腺癌，这表明前列腺癌具有癌前行为。
